NAD+ decline with age: what the research measures
NAD+ supports hundreds of cellular reactions and sirtuin activity. Studies report lower levels with age, but a 2026 replication study has questioned how universal that decline is.
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The language of life, one sequence at a time
Peptide research notes from Senna Research: mechanisms, published studies, analytical testing and handling, for laboratory research use only.
Peptide research fundamentals: storage, evidence and null results
Notes on the groundwork of peptide research: how material is stored, what the evidence does and does not support, and why unglamorous results deserve attention.
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FOXO4-DRI and senescent cells: freeing p53 to restore apoptosis
Senescent cells survive by holding p53 in the nucleus through FOXO4. FOXO4-DRI is a decoy peptide designed to break that bond in preclinical models.
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GHK-Cu plasma decline with age: copper, collagen and gene data
First isolated from human plasma in 1973, GHK-Cu has a gene-expression profile that is directional, not random, and plasma levels that fall by about 60% with age.
Read article →GLP-1 research directions: new fields and combination study design
GLP-1 research now reaches well beyond weight. Notes on where the field is heading and the variables that make combination studies hard to control.
Read article →Peptide purity testing notes: chromatograms, QC and the 95 vs 99 gap
A purity number is only as good as the chromatogram behind it. Notes on HPLC traces, batch QC and why a few percentage points change an experiment.
Read article →GLP-1 receptor expression beyond appetite: heart and brain tissue
GLP-1 is often described as an appetite signal. Receptor expression data from cardiac and brain tissue suggests the signal reaches much further.
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