MOTS-c research: a mitochondrial peptide that declines with age
MOTS-c is encoded by mitochondrial DNA, falls in circulation with age, and rises after aerobic exercise. Most functional evidence still comes from aged mice.
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Longevity & Cellular Aging
Research on senescence, NAD+ metabolism, mitochondrial peptides, and telomere biology.
MOTS-c research: a mitochondrial peptide in metabolic aging
MOTS-c is encoded in mitochondrial DNA, not nuclear DNA. Preclinical work links it to AMPK-like glucose signaling and to metabolic aging.
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NAD+ decline with age: what the research measures
NAD+ supports hundreds of cellular reactions and sirtuin activity. Studies report lower levels with age, but a 2026 replication study has questioned how universal that decline is.
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FOXO4-DRI and senescent cells: freeing p53 to restore apoptosis
Senescent cells survive by holding p53 in the nucleus through FOXO4. FOXO4-DRI is a decoy peptide designed to break that bond in preclinical models.
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