Follistatin 344

Follistatin 344 is a peptide variant derived from the follistatin protein and is commonly studied for its interaction with myostatin and activin-related signaling pathways involved in cellular growth regulation.

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Specifications

Product & molecular data

Lot & handling

SKU: SR-2188
Category: Tissue & Repair Research
Storage: -20 °C, sealed, protected from light
Availability: In stock

Molecular

Sequence: Not available
Molecular formula: Not available
Molecular weight: Not available
CAS number: N/A
Storage conditions: −20 °C sealed and desiccated, protected from light
Format: Lyophilized Vial

Analytics

Testing & quality

When a lot certificate is on file we report identity, purity, and appearance. We publish analytical data only — never dosing information or outcome claims.

RP-HPLC

Chromatographic purity against a qualified reference standard.

LC-MS / ESI-MS

Identity by observed versus theoretical molecular mass.

Karl Fischer / Loss on Drying

Residual moisture in lyophilized material.

Endotoxin & Bioburden

Contaminant screening on raw material and finished lots.

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Research background

Published research context

Summary of the published literature this reference material is used in.

Telomere Biology

Investigated in cell-culture models of telomere maintenance and replicative ageing.

Gene Expression

Studied for reported effects on transcriptional regulation in experimental systems.

Senescence Models

Referenced in literature examining cellular senescence markers in vitro.

Myostatin and Activin Binding

Follistatin is known for its high-affinity binding to members of the TGF-β superfamily, including myostatin and activins [1]. Research models use Follistatin 344 to examine how inhibiting these ligands alters downstream signaling cascades associated with cell growth, differentiation, and tissue modeling. These studies often focus on pathway inhibition mechanics rather than endpoint outcomes.

Growth Regulation Signaling

By neutralizing myostatin activity in experimental systems, Follistatin 344 is used to explore regulatory mechanisms that control cellular growth balance [2]. Researchers assess transcriptional markers, receptor activity, and intracellular signaling changes under controlled conditions to better understand growth-related signaling networks.

Peptide Structure and Research Use

The 344-amino-acid form is frequently referenced in studies examining isoform-specific activity and stability. Its defined sequence allows consistent inclusion in comparative signaling and pathway inhibition studies [1].

Key Specs