VIP

Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino-acid neuropeptide widely distributed throughout the central and peripheral nervous systems. It is studied for its roles in cellular signaling, vascular regulation, secretion, inflammation, and immune function. Supplied strictly for research use only , not for human or veterinary consumption.

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Specifications

Product & molecular data

Lot & handling

SKU: SR-3145
Category: Cognitive & Neuro Research
Storage: -20 °C, sealed, protected from light
Availability: In stock

Molecular

Sequence: Not available
Molecular formula: Not available
Molecular weight: Not available
CAS number: N/A
Storage conditions: −20 °C sealed and desiccated, protected from light
Format: Lyophilized Vial

Analytics

Testing & quality

When a lot certificate is on file we report identity, purity, and appearance. We publish analytical data only — never dosing information or outcome claims.

RP-HPLC

Chromatographic purity against a qualified reference standard.

LC-MS / ESI-MS

Identity by observed versus theoretical molecular mass.

Karl Fischer / Loss on Drying

Residual moisture in lyophilized material.

Endotoxin & Bioburden

Contaminant screening on raw material and finished lots.

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Research background

Published research context

Summary of the published literature this reference material is used in.

Telomere Biology

Investigated in cell-culture models of telomere maintenance and replicative ageing.

Gene Expression

Studied for reported effects on transcriptional regulation in experimental systems.

Senescence Models

Referenced in literature examining cellular senescence markers in vitro.

Overview of VIP in Biochemical Research

Neurotransmission and Cellular Signaling

VIP functions as a neuropeptide and neurotransmitter and is produced by neuronal and immune cells. Research examines VIP receptor signaling and its interactions across nervous, endocrine, and immune systems.[1][2]

Immune and Inflammatory Signaling

VIP has been extensively investigated as an immunoregulatory signaling molecule. Experimental research has examined its effects on immune-cell activation, inflammatory pathways, cytokine responses, and innate immune function.[2][3]

Chemokine Receptor Activity

Laboratory studies have investigated VIP’s effects on chemokine-mediated immune-cell responses. One study reported that VIP inhibited chemokine receptor function in monocytes and CD4+ T lymphocytes, affecting chemotaxis and calcium signaling.[4]

Vascular and Secretory Physiology

VIP is recognized for vasoactive and secretagogue activity. These properties have made VIP signaling an area of research in vascular physiology and the regulation of secretory processes.[1][2]

Molecular and Structural Research

VIP consists of 28 amino acids with the sequence HSDAVFTDNYTRLRKQMAVKKYLNSILN. PubChem lists the molecular formula as C147H237N43O43S and molecular weight as approximately 3326.8 g/mol.[1]

Referenced Citations

PubChem. Vasoactive Intestinal Peptide, CID 53314964. PubChem record
Ganea D, Hooper KM, Kong W. The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases. ⁠PMC
Foster N, Lea SR, Preshaw PM, Taylor JJ. Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease. ⁠PMC
Grimm MC, et al. Vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptors. ⁠PubMed record

For research purposes only. Not for human consumption.