FOXO4-DRI (Proxofim)

FOXO4-DRI is a synthetic peptide designed to disrupt FOXO4-p53 interactions and is studied in cellular senescence and aging pathway research models.

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Specifications

Product & molecular data

Lot & handling

SKU: SR-2191
Category: Longevity & Cellular Research
Storage: -20 °C, sealed, protected from light
Availability: In stock

Molecular

Sequence: Retro-inverso D-amino acid FOXO4 interaction peptide
Molecular formula: C176H291N59O40
Molecular weight: 3757.4 g/mol
CAS number: 2216447-90-1
Storage conditions: −20 °C sealed and desiccated, protected from light
Format: Lyophilized Vial

Analytics

Testing & quality

When a lot certificate is on file we report identity, purity, and appearance. We publish analytical data only — never dosing information or outcome claims.

RP-HPLC

Chromatographic purity against a qualified reference standard.

LC-MS / ESI-MS

Identity by observed versus theoretical molecular mass.

Karl Fischer / Loss on Drying

Residual moisture in lyophilized material.

Endotoxin & Bioburden

Contaminant screening on raw material and finished lots.

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Research background

Published research context

Summary of the published literature this reference material is used in.

Telomere Biology

Investigated in cell-culture models of telomere maintenance and replicative ageing.

Gene Expression

Studied for reported effects on transcriptional regulation in experimental systems.

Senescence Models

Referenced in literature examining cellular senescence markers in vitro.

FOXO4-p53 Interaction Research

FOXO4-DRI was developed to selectively interfere with the binding between FOXO4 and p53, a pathway associated with senescent cell survival [1]. Research models investigate how this disruption influences senescence-associated signaling and transcriptional regulation.

Cellular Senescence Models

Studies involving FOXO4-DRI examine senescent cell markers, apoptosis-related signaling, and stress-response pathways [2]. These investigations contribute to broader research into aging-associated cellular mechanisms.